Coinciding with the art, io9 has provided a brief plot synopsis:
"Let the Games Begin!" Part One: The future looks bright when brilliant and benevolent Dr. Light unveils his latest creations: the Robot Masters! But when the nefarious Dr. Wily steals them for his own sinister purposes, there is no one left to stop him. No one – except Mega Man! Don't miss the first issue of this brand new ongoing series!"
Sounds like your standard run-of-the-mill Mega Man 1 plot. Not like that's a bad thing.
Issue #2 will debut in June, so it looks like we're getting ourselves a monthly serial.
Full scoop at io9.com (via GoNintendo)